A systematic study of gene mutations in urothelial carcinoma: inactivating mutations in TSC2 and PIK3R1

Gottfrid Sjödahl, Martin Lauss, Sigurdur Gudjonsson, Fredrik Liedberg, Christer Halldén, Gunilla Chebil, Wiking Månsson, Mattias Höglund, David Lindgren

Research output: Contribution to journalArticlepeer-review

Abstract

Our data demonstrate a significant association between FGFR3 and PIK3CA mutations in UC. Moreover, the identification of mutations in PIK3R1 further emphasizes the importance of the PI3-kinase pathway in UC. The presence of TSC2 mutations, in addition to TSC1 mutations, underlines the involvement of mTOR signaling in UC.

Original languageEnglish
Pages (from-to)e18583
JournalPLoS ONE
Volume6
Issue number4
DOIs
Publication statusPublished - 2011
Externally publishedYes

Swedish Standard Keywords

  • Medical and Health Sciences (3)

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