Caries-related saliva properties in individuals with 22q11 deletion syndrome

Gunilla Klingberg; Peter Lingström; Sólveig Óskarsdóttir; Vanda Friman; Eva Bohman; Anette Carlén

doi:10.1016/j.tripleo.2006.09.018

Caries-related saliva properties in individuals with 22q11 deletion syndrome

Gunilla Klingberg, Peter Lingström, Sólveig Óskarsdóttir, Vanda Friman, Eva Bohman, Anette Carlén

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Abstract: Objectives. The aims were to compare saliva secretion rate, buffer capacity, cariogenic bacteria, total protein, IgA, and electrolytes between patients with 22q11 deletion syndrome (22q11DS) and control subjects and to study correlations between saliva and serum levels of IgA and electrolytes in 22q11DS patients.

Study design. Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected.

Results. Patients with 22q11DS had impaired salivary secretion rate (P <.01) and buffer capacity (P <.05), higher numbers of cariogenic bacteria (P <.01), increased saliva protein concentrations (P <.001), and reduced output of electrolytes (P <.001 -.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r =.622; P<.01).

Conclusions. Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.

Original language	English
Pages (from-to)	497-504
Number of pages	7
Journal	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume	103
Issue number	4
DOIs	https://doi.org/10.1016/j.tripleo.2006.09.018
Publication status	Published - 2007

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Dentistry (30216)

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10.1016/j.tripleo.2006.09.018

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title = "Caries-related saliva properties in individuals with 22q11 deletion syndrome",

abstract = "Abstract: Objectives. The aims were to compare saliva secretion rate, buffer capacity, cariogenic bacteria, total protein, IgA, and electrolytes between patients with 22q11 deletion syndrome (22q11DS) and control subjects and to study correlations between saliva and serum levels of IgA and electrolytes in 22q11DS patients.Study design. Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected.Results. Patients with 22q11DS had impaired salivary secretion rate (P <.01) and buffer capacity (P <.05), higher numbers of cariogenic bacteria (P <.01), increased saliva protein concentrations (P <.001), and reduced output of electrolytes (P <.001 -.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r =.622; P<.01).Conclusions. Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.",

author = "Gunilla Klingberg and Peter Lingstr{\"o}m and S{\'o}lveig {\'O}skarsd{\'o}ttir and Vanda Friman and Eva Bohman and Anette Carl{\'e}n",

year = "2007",

doi = "10.1016/j.tripleo.2006.09.018",

language = "English",

volume = "103",

pages = "497--504",

journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics",

issn = "1079-2104",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Caries-related saliva properties in individuals with 22q11 deletion syndrome

AU - Klingberg, Gunilla

AU - Lingström, Peter

AU - Óskarsdóttir, Sólveig

AU - Friman, Vanda

AU - Bohman, Eva

AU - Carlén, Anette

PY - 2007

Y1 - 2007

N2 - Abstract: Objectives. The aims were to compare saliva secretion rate, buffer capacity, cariogenic bacteria, total protein, IgA, and electrolytes between patients with 22q11 deletion syndrome (22q11DS) and control subjects and to study correlations between saliva and serum levels of IgA and electrolytes in 22q11DS patients.Study design. Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected.Results. Patients with 22q11DS had impaired salivary secretion rate (P <.01) and buffer capacity (P <.05), higher numbers of cariogenic bacteria (P <.01), increased saliva protein concentrations (P <.001), and reduced output of electrolytes (P <.001 -.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r =.622; P<.01).Conclusions. Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.

AB - Abstract: Objectives. The aims were to compare saliva secretion rate, buffer capacity, cariogenic bacteria, total protein, IgA, and electrolytes between patients with 22q11 deletion syndrome (22q11DS) and control subjects and to study correlations between saliva and serum levels of IgA and electrolytes in 22q11DS patients.Study design. Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected.Results. Patients with 22q11DS had impaired salivary secretion rate (P <.01) and buffer capacity (P <.05), higher numbers of cariogenic bacteria (P <.01), increased saliva protein concentrations (P <.001), and reduced output of electrolytes (P <.001 -.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r =.622; P<.01).Conclusions. Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.

U2 - 10.1016/j.tripleo.2006.09.018

DO - 10.1016/j.tripleo.2006.09.018

M3 - Article

SN - 1079-2104

VL - 103

SP - 497

EP - 504

JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

IS - 4

ER -

Caries-related saliva properties in individuals with 22q11 deletion syndrome

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