Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Mireia Obón-Santacana; Leila Luján-Barroso; Heinz Freisling; Sabine Naudin; Marie-Christine Boutron-Ruault; Francesca Romana Mancini; Vinciane Rebours; Tilman Kühn; Verena Katzke; Heiner Boeing; Anne Tjønneland; Anja Olsen; Kim Overvad; Cristina Lasheras; Miguel Rodríguez-Barranco; Pilar Amiano; Carmen Santiuste; Eva Ardanaz; Kay-Thee Khaw; Nicholas J Wareham; Julie A Schmidt; Dagfinn Aune; Antonia Trichopoulou; Paschalis Thriskos; Eleni Peppa; Giovanna Masala; Sara Grioni; Rosario Tumino; Salvatore Panico; Bas Bueno-de-Mesquita; Veronica Sciannameo; Roel Vermeulen; Emily Sonestedt; Malin Sund; Elisabete Weiderpass; Guri Skeie; Carlos A González; Elio Riboli; Eric J Duell

doi:10.1002/ijc.32415

Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Mireia Obón-Santacana
, Leila Luján-Barroso
, Heinz Freisling
, Sabine Naudin
, Marie-Christine Boutron-Ruault
, Francesca Romana Mancini
, Vinciane Rebours
, Tilman Kühn
, Verena Katzke
, Heiner Boeing
, Anne Tjønneland
, Anja Olsen
, Kim Overvad
, Cristina Lasheras
, Miguel Rodríguez-Barranco
, Pilar Amiano
, Carmen Santiuste
, Eva Ardanaz
, Kay-Thee Khaw
, Nicholas J Wareham

Julie A Schmidt, Dagfinn Aune, Antonia Trichopoulou, Paschalis Thriskos, Eleni Peppa, Giovanna Masala, Sara Grioni, Rosario Tumino, Salvatore Panico, Bas Bueno-de-Mesquita, Veronica Sciannameo, Roel Vermeulen, Emily Sonestedt, Malin Sund, Elisabete Weiderpass, Guri Skeie, Carlos A González, Elio Riboli, Eric J Duell

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Original language	English
Pages (from-to)	76-84
Number of pages	9
Journal	International Journal of Cancer
Volume	146
Issue number	1
DOIs	https://doi.org/10.1002/ijc.32415
Publication status	Published - 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Carcinoma, Pancreatic Ductal/etiology
Diet
Europe
Female
Humans
Male
Middle Aged
Nuts
Pancreatic Neoplasms/etiology
Proportional Hazards Models
Prospective Studies
Risk Factors
Seeds
Surveys and Questionnaires

Access to Document

10.1002/ijc.32415

Cite this

Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F. R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., ... Duell, E. J. (2019). Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 146(1), 76-84. https://doi.org/10.1002/ijc.32415

@article{ca8e2d4a621746dca19007bbae15ef20,

title = "Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition",

abstract = "Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95\% confidence intervals (95\% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95\% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.",

keywords = "Carcinoma, Pancreatic Ductal/etiology, Diet, Europe, Female, Humans, Male, Middle Aged, Nuts, Pancreatic Neoplasms/etiology, Proportional Hazards Models, Prospective Studies, Risk Factors, Seeds, Surveys and Questionnaires",

author = "Mireia Ob{\'o}n-Santacana and Leila Luj{\'a}n-Barroso and Heinz Freisling and Sabine Naudin and Marie-Christine Boutron-Ruault and Mancini, \{Francesca Romana\} and Vinciane Rebours and Tilman K{\"u}hn and Verena Katzke and Heiner Boeing and Anne Tj{\o}nneland and Anja Olsen and Kim Overvad and Cristina Lasheras and Miguel Rodr{\'i}guez-Barranco and Pilar Amiano and Carmen Santiuste and Eva Ardanaz and Kay-Thee Khaw and Wareham, \{Nicholas J\} and Schmidt, \{Julie A\} and Dagfinn Aune and Antonia Trichopoulou and Paschalis Thriskos and Eleni Peppa and Giovanna Masala and Sara Grioni and Rosario Tumino and Salvatore Panico and Bas Bueno-de-Mesquita and Veronica Sciannameo and Roel Vermeulen and Emily Sonestedt and Malin Sund and Elisabete Weiderpass and Guri Skeie and Gonz{\'a}lez, \{Carlos A\} and Elio Riboli and Duell, \{Eric J\}",

note = "{\textcopyright} 2019 UICC.",

year = "2019",

doi = "10.1002/ijc.32415",

language = "English",

volume = "146",

pages = "76--84",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

Obón-Santacana, M, Luján-Barroso, L, Freisling, H, Naudin, S, Boutron-Ruault, M-C, Mancini, FR, Rebours, V, Kühn, T, Katzke, V, Boeing, H, Tjønneland, A, Olsen, A, Overvad, K, Lasheras, C, Rodríguez-Barranco, M, Amiano, P, Santiuste, C, Ardanaz, E, Khaw, K-T, Wareham, NJ, Schmidt, JA, Aune, D, Trichopoulou, A, Thriskos, P, Peppa, E, Masala, G, Grioni, S, Tumino, R, Panico, S, Bueno-de-Mesquita, B, Sciannameo, V, Vermeulen, R, Sonestedt, E, Sund, M, Weiderpass, E, Skeie, G, González, CA, Riboli, E & Duell, EJ 2019, 'Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 146, no. 1, pp. 76-84. https://doi.org/10.1002/ijc.32415

TY - JOUR

T1 - Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

AU - Obón-Santacana, Mireia

AU - Luján-Barroso, Leila

AU - Freisling, Heinz

AU - Naudin, Sabine

AU - Boutron-Ruault, Marie-Christine

AU - Mancini, Francesca Romana

AU - Rebours, Vinciane

AU - Kühn, Tilman

AU - Katzke, Verena

AU - Boeing, Heiner

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Lasheras, Cristina

AU - Rodríguez-Barranco, Miguel

AU - Amiano, Pilar

AU - Santiuste, Carmen

AU - Ardanaz, Eva

AU - Khaw, Kay-Thee

AU - Wareham, Nicholas J

AU - Schmidt, Julie A

AU - Aune, Dagfinn

AU - Trichopoulou, Antonia

AU - Thriskos, Paschalis

AU - Peppa, Eleni

AU - Masala, Giovanna

AU - Grioni, Sara

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Bueno-de-Mesquita, Bas

AU - Sciannameo, Veronica

AU - Vermeulen, Roel

AU - Sonestedt, Emily

AU - Sund, Malin

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - González, Carlos A

AU - Riboli, Elio

AU - Duell, Eric J

PY - 2019

Y1 - 2019

N2 - Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

AB - Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

KW - Carcinoma, Pancreatic Ductal/etiology

KW - Diet

KW - Europe

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Nuts

KW - Pancreatic Neoplasms/etiology

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Factors

KW - Seeds

KW - Surveys and Questionnaires

U2 - 10.1002/ijc.32415

DO - 10.1002/ijc.32415

M3 - Article

C2 - 31107546

SN - 0020-7136

VL - 146

SP - 76

EP - 84

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 1

ER -

Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Abstract

UN SDGs

Keywords

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