TY - JOUR
T1 - Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population-based cross-sectional study
T2 - RANTES was associated with periodontitis
AU - Söderlin, Maria K
AU - Persson, Gösta Rutger
AU - Renvert, Stefan
AU - Sanmartin Berglund, Johan
N1 - Funding Information:
We wish to thank registered nurses Pia Jansson and Anna Andersson for help with the recruitment of the patients and Ms. Ulrika Isaksson for data management. We appreciate the work by RDS Ingrid Jonasson for the dental examinations. We also wish to thank Mr. Hans Krona for help with the analyses of the blood samples. This work was supported by the Eklund Foundation (to SR), Region Blekinge (to MKS), the Crafoord Foundation (to MKS) and the Swedish Rheumatism Association (to MKS).
Funding Information:
We wish to thank registered nurses Pia Jansson and Anna Andersson for help with the recruitment of the patients and Ms. Ulrika Isaksson for data management. We appreciate the work by RDS Ingrid Jonasson for the dental examinations. We also wish to thank Mr. Hans Krona for help with the analyses of the blood samples. This work was supported by the Eklund Foundation (to SR), Region Blekinge (to MKS), the Crafoord Foundation (to MKS) and the Swedish Rheumatism Association (to MKS).
Publisher Copyright:
© 2021 The Authors. Journal of Periodontal Research published by John Wiley & Sons Ltd.
PY - 2021
Y1 - 2021
N2 - OBJECTIVE: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis.BACKGROUND DATA: Earlier studies on cytokines in GCF in RA patients have not given clear results.METHODS: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1-β (IL-1β), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and chemokines RANTES/CCL5, eotaxin and monocyte chemoattractant protein (MCP-1) were analyzed in GCF. These cytokines were stratified for periodontitis, age, gender, body mass index (BMI), smoking, and anti-cyclic citrullinated protein (anti-CCP) status. Binary logistic regression analyses with periodontitis as outcome were performed adjusting for the above mentioned confounding factors including anti-rheumatic medication, disease duration and the cytokine in question.RESULTS: Periodontitis was diagnosed in 80/132 (61%) of study participants. The 110 RA patients not participating were older, had a higher mean erythrocyte sedimentation rate (ESR), had a higher mean DAS28ESR (Disease Activity Score 28 using ESR) and were less often on biologic treatment. Only RANTES was associated with periodontitis (p = .049, OR 1.001, 95% CI 1.000-1.002) in the binary logistic regression analyses.CONCLUSION: In this population-based elderly RA cohort, neither pro-inflammatory nor anti-inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.
AB - OBJECTIVE: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis.BACKGROUND DATA: Earlier studies on cytokines in GCF in RA patients have not given clear results.METHODS: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1-β (IL-1β), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and chemokines RANTES/CCL5, eotaxin and monocyte chemoattractant protein (MCP-1) were analyzed in GCF. These cytokines were stratified for periodontitis, age, gender, body mass index (BMI), smoking, and anti-cyclic citrullinated protein (anti-CCP) status. Binary logistic regression analyses with periodontitis as outcome were performed adjusting for the above mentioned confounding factors including anti-rheumatic medication, disease duration and the cytokine in question.RESULTS: Periodontitis was diagnosed in 80/132 (61%) of study participants. The 110 RA patients not participating were older, had a higher mean erythrocyte sedimentation rate (ESR), had a higher mean DAS28ESR (Disease Activity Score 28 using ESR) and were less often on biologic treatment. Only RANTES was associated with periodontitis (p = .049, OR 1.001, 95% CI 1.000-1.002) in the binary logistic regression analyses.CONCLUSION: In this population-based elderly RA cohort, neither pro-inflammatory nor anti-inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.
KW - cytokines
KW - gingival crevicular fluid
KW - periodontitis
KW - rheumatoid arthritis
KW - Cross-Sectional Studies
KW - Periodontitis
KW - Gingival Crevicular Fluid/chemistry
KW - Humans
KW - Arthritis, Rheumatoid/drug therapy
KW - Chemokine CCL5/analysis
KW - Aged
KW - Cytokines/analysis
U2 - 10.1111/jre.12887
DO - 10.1111/jre.12887
M3 - Article
C2 - 33954982
SN - 0022-3484
VL - 56
SP - 907
EP - 916
JO - Journal of Periodontal Research
JF - Journal of Periodontal Research
IS - 5
ER -