Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries

Thibault Fiolet; Corinne Casagrande; Geneviève Nicolas; Zsuzsanna Horvath; Pauline Frenoy; Elisabete Weiderpass; Verena Katzke; Rudolf Kaaks; Miguel Rodriguez-Barranco; Salvatore Panico; Carlotta Sacerdote; Jonas Manjer; Emily Sonestedt; Sara Grioni; Antonio Agudo; Charlotta Rylander; Therese Haugdahl Nøst; Guri Skeie; Anne Tjønneland; Ole Raaschou-Nielsen; Eva Ardanaz; Pilar Amiano; María Dolores Chirlaque López; Matthias B Schulze; Maria Wennberg; Sophia Harlid; Manon Cairat; Marina Kvaskoff; Inge Huybrechts; Francesca Romana Mancini

doi:10.1016/j.envint.2022.107213

Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries

Thibault Fiolet, Corinne Casagrande, Geneviève Nicolas, Zsuzsanna Horvath, Pauline Frenoy, Elisabete Weiderpass, Verena Katzke, Rudolf Kaaks, Miguel Rodriguez-Barranco, Salvatore Panico, Carlotta Sacerdote, Jonas Manjer, Emily Sonestedt, Sara Grioni, Antonio Agudo, Charlotta Rylander, Therese Haugdahl Nøst, Guri Skeie, Anne Tjønneland, Ole Raaschou-NielsenEva Ardanaz, Pilar Amiano, María Dolores Chirlaque López, Matthias B Schulze, Maria Wennberg, Sophia Harlid, Manon Cairat, Marina Kvaskoff, Inge Huybrechts, Francesca Romana Mancini

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

BACKGROUND: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure.

METHODS: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5-16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority.

RESULTS: Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HRdioxins = 1.00 (0.98 to 1.02), HRdioxins+DL-PCB = 1.01 (0.98 to 1.03), HRDL-PCB = 1.01 (0.98 to 1.03), and HRNDL-PCB = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors.

CONCLUSIONS: This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.

Original language	English
Article number	107213
Journal	Environment International
Volume	163
DOIs	https://doi.org/10.1016/j.envint.2022.107213
Publication status	Published - 2022-May
Externally published	Yes

Swedish Standard Keywords

Health Sciences (303)

Keywords

Adult
Breast Neoplasms/epidemiology
Dioxins/adverse effects
Eating
Female
Food Contamination/analysis
Humans
Middle Aged
Polychlorinated Biphenyls/adverse effects
Prospective Studies

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.envint.2022.107213

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Fiolet, T., Casagrande, C., Nicolas, G., Horvath, Z., Frenoy, P., Weiderpass, E., Katzke, V., Kaaks, R., Rodriguez-Barranco, M., Panico, S., Sacerdote, C., Manjer, J., Sonestedt, E., Grioni, S., Agudo, A., Rylander, C., Haugdahl Nøst, T., Skeie, G., Tjønneland, A., ... Romana Mancini, F. (2022). Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries. Environment International, 163, Article 107213. https://doi.org/10.1016/j.envint.2022.107213

@article{ddbc9ce6f83244c8a746059805bf4eef,

title = "Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries",

abstract = "BACKGROUND: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure.METHODS: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5-16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority.RESULTS: Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HRdioxins = 1.00 (0.98 to 1.02), HRdioxins+DL-PCB = 1.01 (0.98 to 1.03), HRDL-PCB = 1.01 (0.98 to 1.03), and HRNDL-PCB = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors.CONCLUSIONS: This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.",

keywords = "Adult, Breast Neoplasms/epidemiology, Dioxins/adverse effects, Eating, Female, Food Contamination/analysis, Humans, Middle Aged, Polychlorinated Biphenyls/adverse effects, Prospective Studies",

author = "Thibault Fiolet and Corinne Casagrande and Genevi{\`e}ve Nicolas and Zsuzsanna Horvath and Pauline Frenoy and Elisabete Weiderpass and Verena Katzke and Rudolf Kaaks and Miguel Rodriguez-Barranco and Salvatore Panico and Carlotta Sacerdote and Jonas Manjer and Emily Sonestedt and Sara Grioni and Antonio Agudo and Charlotta Rylander and {Haugdahl N{\o}st}, Therese and Guri Skeie and Anne Tj{\o}nneland and Ole Raaschou-Nielsen and Eva Ardanaz and Pilar Amiano and {Dolores Chirlaque L{\'o}pez}, Mar{\'i}a and Schulze, {Matthias B} and Maria Wennberg and Sophia Harlid and Manon Cairat and Marina Kvaskoff and Inge Huybrechts and {Romana Mancini}, Francesca",

note = "Copyright {\textcopyright} 2022. Published by Elsevier Ltd.",

year = "2022",

month = may,

doi = "10.1016/j.envint.2022.107213",

language = "English",

volume = "163",

journal = "Environment International",

issn = "0160-4120",

publisher = "Elsevier Ltd.",

}

Fiolet, T, Casagrande, C, Nicolas, G, Horvath, Z, Frenoy, P, Weiderpass, E, Katzke, V, Kaaks, R, Rodriguez-Barranco, M, Panico, S, Sacerdote, C, Manjer, J, Sonestedt, E, Grioni, S, Agudo, A, Rylander, C, Haugdahl Nøst, T, Skeie, G, Tjønneland, A, Raaschou-Nielsen, O, Ardanaz, E, Amiano, P, Dolores Chirlaque López, M, Schulze, MB, Wennberg, M, Harlid, S, Cairat, M, Kvaskoff, M, Huybrechts, I & Romana Mancini, F 2022, 'Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries', Environment International, vol. 163, 107213. https://doi.org/10.1016/j.envint.2022.107213

TY - JOUR

T1 - Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries

AU - Fiolet, Thibault

AU - Casagrande, Corinne

AU - Nicolas, Geneviève

AU - Horvath, Zsuzsanna

AU - Frenoy, Pauline

AU - Weiderpass, Elisabete

AU - Katzke, Verena

AU - Kaaks, Rudolf

AU - Rodriguez-Barranco, Miguel

AU - Panico, Salvatore

AU - Sacerdote, Carlotta

AU - Manjer, Jonas

AU - Sonestedt, Emily

AU - Grioni, Sara

AU - Agudo, Antonio

AU - Rylander, Charlotta

AU - Haugdahl Nøst, Therese

AU - Skeie, Guri

AU - Tjønneland, Anne

AU - Raaschou-Nielsen, Ole

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Dolores Chirlaque López, María

AU - Schulze, Matthias B

AU - Wennberg, Maria

AU - Harlid, Sophia

AU - Cairat, Manon

AU - Kvaskoff, Marina

AU - Huybrechts, Inge

AU - Romana Mancini, Francesca

PY - 2022/5

Y1 - 2022/5

N2 - BACKGROUND: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure.METHODS: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5-16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority.RESULTS: Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HRdioxins = 1.00 (0.98 to 1.02), HRdioxins+DL-PCB = 1.01 (0.98 to 1.03), HRDL-PCB = 1.01 (0.98 to 1.03), and HRNDL-PCB = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors.CONCLUSIONS: This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.

AB - BACKGROUND: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure.METHODS: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5-16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority.RESULTS: Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HRdioxins = 1.00 (0.98 to 1.02), HRdioxins+DL-PCB = 1.01 (0.98 to 1.03), HRDL-PCB = 1.01 (0.98 to 1.03), and HRNDL-PCB = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors.CONCLUSIONS: This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.

KW - Adult

KW - Breast Neoplasms/epidemiology

KW - Dioxins/adverse effects

KW - Eating

KW - Female

KW - Food Contamination/analysis

KW - Humans

KW - Middle Aged

KW - Polychlorinated Biphenyls/adverse effects

KW - Prospective Studies

U2 - 10.1016/j.envint.2022.107213

DO - 10.1016/j.envint.2022.107213

M3 - Article

C2 - 35364416

SN - 0160-4120

VL - 163

JO - Environment International

JF - Environment International

M1 - 107213

ER -

Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries

Abstract

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Keywords

UN SDGs

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