Dyskinesias following neural transplantation in Parkinson's disease.

Peter Hagell; Paola Piccini; Anders Björklund; Patrik Brundin; Stig Rehncrona; Håkan Widner; Lesley Crabb; Nicola Pavese; Wolfgang H Oertel; Niall Quinn; David J Brooks; Olle Lindvall

doi:10.1038/nn863

Dyskinesias following neural transplantation in Parkinson's disease.

Peter Hagell, Paola Piccini, Anders Björklund, Patrik Brundin, Stig Rehncrona, Håkan Widner, Lesley Crabb, Nicola Pavese, Wolfgang H Oertel, Niall Quinn, David J Brooks, Olle Lindvall

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Abstract

Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.

Original language	English
Pages (from-to)	627-628
Number of pages	1
Journal	Nature Neuroscience
Volume	5
Issue number	7
DOIs	https://doi.org/10.1038/nn863
Publication status	Published - 2002
Externally published	Yes

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Clinical Medicine (302)

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title = "Dyskinesias following neural transplantation in Parkinson's disease.",

abstract = "Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.",

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T1 - Dyskinesias following neural transplantation in Parkinson's disease.

AU - Hagell, Peter

AU - Piccini, Paola

AU - Björklund, Anders

AU - Brundin, Patrik

AU - Rehncrona, Stig

AU - Widner, Håkan

AU - Crabb, Lesley

AU - Pavese, Nicola

AU - Oertel, Wolfgang H

AU - Quinn, Niall

AU - Brooks, David J

AU - Lindvall, Olle

PY - 2002

Y1 - 2002

N2 - Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.

AB - Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.

U2 - 10.1038/nn863

DO - 10.1038/nn863

M3 - Article

SN - 1097-6256

VL - 5

SP - 627

EP - 628

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 7

ER -

Dyskinesias following neural transplantation in Parkinson's disease.

Abstract

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