Fully uncomplexed cyclodextrin in mixed systems of vesicle-cyclodextrin: solvolysis of benzoyl chlorides.

Celia Cabaleiro-Lago, L García-Río, P Hervés, J Pérez-Juste

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

In this contribution the influence of beta-cyclodextrin (CD) on the behavior of aqueous systems containing vesicles of dipalmitoyl phosphatidyl choline (DPPC) has been studied by determining the kinetics of the solvolysis reaction of substituted benzoyl chlorides whose solvolysis reactivity entails a high sensitivity on media properties. The application of the pseudophase formalism allowed us to obtain the thermodynamic and kinetic coefficients characteristic of the reaction, which are essentially independent of the concentration of CD. We were able to determine the percentages of uncomplexed cyclodextrin in equilibrium with the vesicular system which were in all cases compatible with 100%. The obtained results led us to conclude that the properties of DPPC vesicles are not affected by the presence of CD in the medium and there is no type of interaction between the CD and the vesicular surfactant monomers and, therefore, all cyclodextrin is present in the mixed system as uncomplexed cyclodextrin.

Original languageEnglish
Pages (from-to)6749-6755
Number of pages6
JournalJournal of Physical Chemistry B
Volume113
Issue number19
DOIs
Publication statusPublished - 2009
Externally publishedYes

Swedish Standard Keywords

  • Physical Chemistry (10402)

Keywords

  • Beta-cyclodextrin
  • Synthetic amphiphile vesicles
  • basic hydrolysis
  • kemp elimination
  • micellar media
  • mimetic reaction media
  • nitroso-p-toluenesulfonamide
  • probing catalytic properties
  • reactivity
  • surfactant complexation

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