IL-1RN gene polymorphism is associated with peri-implantitis.

Marja L Laine, Asa Leonhardt, Ann-Marie Roos-Jansåker, A Salvador Peña, Arie Jan van Winkelhoff, Edwin G Winkel, Stefan Renvert

    Research output: Contribution to journalArticlepeer-review

    97 Citations (Scopus)

    Abstract

    OBJECTIVES: Interleukin (IL)-1alpha, IL-1beta and their natural specific inhibitor IL-1 receptor antagonist (IL-1ra) play a key role in the regulation of the inflammatory response in periodontal tissues. Polymorphisms in the IL-1 gene cluster have been associated with severe adult periodontitis. We aimed to investigate the IL-1 gene cluster polymorphisms in patients with peri-implantitis.

    MATERIAL AND METHODS: The study included 120 North Caucasian individuals. A total of 71 patients (mean age 68 years, 76% smokers) demonstrating peri-implantitis at one or more implants as evidenced by bleeding and/or pus on probing and bone loss amounting to >3 threads on Brånemark implants and 49 controls (mean age 66 years, 45% smokers) with clinical healthy mucosa and no bone loss around the implants were recruited for the study. The titanium implants, ad modum Brånemark, had been in function for at least 2 years. Mouthwash samples were collected and used for genotyping of the bi-allelic polymorphisms IL-1A(-889), IL-1B(+3953), IL-1B(-511) and a variable number of tandem repeat IL-1RN gene polymorphisms using PCR technique.

    RESULTS: Significant differences were found in the carriage rate of allele 2 in the IL-1RN gene between peri-implantitis patients and controls (56.5% vs. 33.3%, respectively; odds ratios (OR) 2.6; 95% confidence interval (CI) 1.2-5.6; P=0.015). Logistic regression analysis taking smoking, gender and age into account confirmed the association between the IL-1RN allele 2 carriers and peri-implantitis (OR 3; 95% CI 1.2-7.6; P=0.02).

    CONCLUSIONS: Our results provide evidence that IL-1RN gene polymorphism is associated with peri-implantitis and may represent a risk factor for this disease.

    Original languageEnglish
    Pages (from-to)380-385
    Number of pages5
    JournalClinical Oral Implants Research
    Volume17
    Issue number4
    DOIs
    Publication statusPublished - 2006

    Swedish Standard Keywords

    • Dentistry (30216)

    Keywords

    • Intervention
    • Palliative care approach
    • Residential care facilities

    Fingerprint

    Dive into the research topics of 'IL-1RN gene polymorphism is associated with peri-implantitis.'. Together they form a unique fingerprint.

    Cite this