Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: Lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls

Marie Fridberg; Sofia Kjellström; Lola Anagnostaki; Ingela Skogvall; Tomas Mustelin; Thomas Wiebe; Jenny L. Persson; Michael Dictor; Anette Gjörloff Wingren

doi:10.1080/08880010802237054

Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: Lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls

Marie Fridberg, Sofia Kjellström, Lola Anagnostaki, Ingela Skogvall, Tomas Mustelin, Thomas Wiebe, Jenny L. Persson, Michael Dictor, Anette Gjörloff Wingren

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.

Original language	English
Pages (from-to)	528-540
Number of pages	13
Journal	Pediatric Hematology and Oncology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1080/08880010802237054
Publication status	Published - 2008-Aug
Externally published	Yes

Swedish Standard Keywords

Clinical Medicine (302)

Keywords

Burkitt
Immunohistochemistry
Lymphoma
Pediatric
Protein tyrosine phosphatase

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10.1080/08880010802237054

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Fridberg, M., Kjellström, S., Anagnostaki, L., Skogvall, I., Mustelin, T., Wiebe, T., Persson, J. L., Dictor, M., & Wingren, A. G. (2008). Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: Lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls. Pediatric Hematology and Oncology, 25(6), 528-540. https://doi.org/10.1080/08880010802237054

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title = "Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: Lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls",

abstract = "Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.",

keywords = "Burkitt, Immunohistochemistry, Lymphoma, Pediatric, Protein tyrosine phosphatase",

author = "Marie Fridberg and Sofia Kjellstr{\"o}m and Lola Anagnostaki and Ingela Skogvall and Tomas Mustelin and Thomas Wiebe and Persson, {Jenny L.} and Michael Dictor and Wingren, {Anette Gj{\"o}rloff}",

note = "Funding Information: The authors thank Elise Nilsson for invaluable technical assistance. This work was supported by grants from the American Cancer Society for technology transfer, the Swedish Childrens Cancer Foundation, the Alfred {\"O}sterlund Foundation, the Magnus Bergvall Foundation, the Medical Faculty of Lund, Svenska L{\"a}kares{\"a}llskapet, the Siv-Inger and Per-Erik Andersson Foundation, the Berta Kamprad Foundation, the Cancer Foundation at Malm{\"o} University Hospital, and the Ellen Bachrach{\textquoteright}s Children{\textquoteright}s Cancer Foundation of Haematology.",

year = "2008",

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doi = "10.1080/08880010802237054",

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Fridberg, M, Kjellström, S, Anagnostaki, L, Skogvall, I, Mustelin, T, Wiebe, T, Persson, JL, Dictor, M & Wingren, AG 2008, 'Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: Lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls', Pediatric Hematology and Oncology, vol. 25, no. 6, pp. 528-540. https://doi.org/10.1080/08880010802237054

Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: Lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls. / Fridberg, Marie; Kjellström, Sofia; Anagnostaki, Lola et al.
In: Pediatric Hematology and Oncology, Vol. 25, No. 6, 08.2008, p. 528-540.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma

T2 - Lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls

AU - Fridberg, Marie

AU - Kjellström, Sofia

AU - Anagnostaki, Lola

AU - Skogvall, Ingela

AU - Mustelin, Tomas

AU - Wiebe, Thomas

AU - Persson, Jenny L.

AU - Dictor, Michael

AU - Wingren, Anette Gjörloff

N1 - Funding Information: The authors thank Elise Nilsson for invaluable technical assistance. This work was supported by grants from the American Cancer Society for technology transfer, the Swedish Childrens Cancer Foundation, the Alfred Österlund Foundation, the Magnus Bergvall Foundation, the Medical Faculty of Lund, Svenska Läkaresällskapet, the Siv-Inger and Per-Erik Andersson Foundation, the Berta Kamprad Foundation, the Cancer Foundation at Malmö University Hospital, and the Ellen Bachrach’s Children’s Cancer Foundation of Haematology.

PY - 2008/8

Y1 - 2008/8

N2 - Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.

AB - Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.

KW - Burkitt

KW - Immunohistochemistry

KW - Lymphoma

KW - Pediatric

KW - Protein tyrosine phosphatase

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JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

IS - 6

ER -

Fridberg M, Kjellström S, Anagnostaki L, Skogvall I, Mustelin T, Wiebe T et al. Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: Lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls. Pediatric Hematology and Oncology. 2008 Aug;25(6):528-540. doi: 10.1080/08880010802237054