In search of fully uncomplexed cyclodextrin in the presence of micellar aggregates

Celia Cabaleiro-Lago, L. Garcia-Rio, P. Herves, J. C. Mejuto, J. Perez-Juste

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22 Citations (Scopus)

Abstract

The chemical behavior of beta-cyclodextrin/nonionic surfactant mixed systems has been investigated using the basic hydrolysis of N-methyl-N-nitroso-p-toluenesulfonamide as a chemical probe. The experimental results prove that at the cmc, there are significant quantities of uncomplexed beta-CD in equilibrium with the micellar aggregates. In contrast to the expected situation, the percentage of uncomplexed beta-CD in equilibrium with the micellar system increases on increasing the hydrophobicity of the surfactant molecule. This behavior is due to the existence of two simultaneous processes: complexation of surfactant monomers by cyclodextrin and the process of self-assembly to form micellar aggregates. The autoaggregation of surfactant monomers is expected to be more important than the complexation process in this mixed system. Varying the hydrophobicity of the surfactant monomer enabled us to determine that the percentages of uncomplexed cyclodextrin in equilibrium with the micellar system were in the range of 5-95%.

Original languageEnglish
Pages (from-to)15831-15838
Number of pages7
JournalJournal of Physical Chemistry B
Volume110
Issue number32
DOIs
Publication statusPublished - 2006
Externally publishedYes

Swedish Standard Keywords

  • Physical Chemistry (10402)

Keywords

  • Alpha-cyclodextrins
  • Beta-cyclodextrin
  • Sodium dodecyl-sulfate
  • aqueous-solutions
  • basix hydrolysis
  • binding constants
  • dodecyl trimethylammonium bromide
  • gemini surfactant
  • surfactant inclusion complexes
  • thermodynamic properties

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