Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

Jia-Yi Li, Elisabet Englund, Janice L. Holton, Denis Soulet, Peter Hagell, Andrew J. Lees, Tammaryn Lashley, Niall P Quinn, Stig Rehncrona, Anders Björklund, Håkan Widner, Tamas Revesz, Olle Lindvall, Patrik Brundin

Research output: Contribution to journalArticlepeer-review

1231 Citations (Scopus)

Abstract

Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

Original languageEnglish
Pages (from-to)501-503
Number of pages2
JournalNature Medicine
Volume14
Issue number5
DOIs
Publication statusPublished - 2008
Externally publishedYes

Swedish Standard Keywords

  • Neurology (30207)

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