Mixture effects of 3 mechanistically different steroidogenic disruptors (prochloraz, genistein, and ketoconazole) in the H295R cell assay

Keyphrases

• Ketoconazole 100%
• H295R Cells 100%
• Steroidogenic Pathway 100%
• Genistein 100%
• Mixture Effects 100%
• Prochloraz 100%
• Disruptor 100%
• Cell-based Assay 100%
• Steroidogenic 100%
• Mode of Action 75%
• Endocrine Disruptors 75%
• H295R Cell Line 50%
• Steroidogenesis 50%
• Gas Chromatography-mass Spectrometry 50%
• Concentration Addition 50%
• Chemical Analysis 25%
• Tandem Mass Spectrometry 25%
• Modeling Approach 25%
• Progesterone 25%
• Dehydroepiandrosterone 25%
• Pregnenolone 25%
• Estrone 25%
• Steroid Hormones 25%
• Androstenedione 25%
• Testosterone 25%
• 17-estradiol 25%
• EC50 25%
• Sex Steroids 25%
• Mixture Toxicity 25%
• Antagonistic Effect 25%
• Adrenocortical 25%
• Lowest Observed Effect Concentration 25%
• Opposite Effects 25%
• Current Modeling 25%
• Additivity 25%

Medicine and Dentistry

• Genistein 100%
• Endocrine Disruptor 100%
• Prochloraz 100%
• Ketoconazole 100%
• Cell Line 66%
• Steroidogenesis 66%
• Gas Chromatography Mass Spectrometry 66%
• Tandem Mass Spectrometry 33%
• Tandem Mass Spectrometry 33%
• Steroid Hormone 33%
• Estrone 33%
• Progesterone 33%
• Concentration Effect 33%
• Sex Hormone 33%
• Prasterone 33%
• Androstenedione 33%
• Diethylstilbestrol 33%
• Pregnenolone 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Ketoconazole 100%
• Endocrine Disruptor 100%
• Prochloraz 100%
• Genistein 100%
• Progesterone 33%
• Androstenedione 33%
• Pregnenolone 33%
• Steroid Hormone 33%
• Diethylstilbestrol 33%
• Prasterone 33%
• Estrone 33%
• Sex Hormone 33%
• EC50 33%