No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No-go task: an fMRI study.

Audun S Welander-Vatn; Jimmy Jensen; Christine Lycke; Ingrid Agartz; Andres Server; Øystein Bech Gadmar; Ingrid Melle; Per Hjalmar Nakstad; Ole A Andreassen

doi:10.1111/j.1399-5618.2009.00680.x

No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No-go task: an fMRI study.

Audun S Welander-Vatn, Jimmy Jensen, Christine Lycke, Ingrid Agartz, Andres Server, Øystein Bech Gadmar, Ingrid Melle, Per Hjalmar Nakstad, Ole A Andreassen

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

OBJECTIVES: It has been reported that one of the core features in patients with bipolar disorder II (BD II) is increased impulsivity. The aim of this study was to investigate whether patients with BD II showed decreased activation in the dorsal anterior cingulate cortex (dACC) as compared to healthy controls when performing a task sensitive to impulsivity.

METHODS: Twenty-seven BD II patients and 28 healthy controls performed a Go/No-go task during a functional magnetic resonance imaging (fMRI) session. Eleven of the patients were unmedicated, and possible group differences between medicated and unmedicated patients were also assessed. Results: The groups did not differ in behavioral performance on the Go/No-go task. Both BD II subjects and healthy controls demonstrated dACC activity during the task, and analyses revealed no statistically significant group differences. Medicated and unmedicated patients also did not differ in the degree of fMRI activation.

CONCLUSIONS: These findings do not support the hypothesis of abnormal dACC activity during a Go/No-go task in BD II patients.

Original language	English
Pages (from-to)	270-279
Number of pages	9
Journal	Bipolar Disorders
Volume	11
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-5618.2009.00680.x
Publication status	Published - 2009
Externally published	Yes

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Neurosciences (30105)
Psychiatry (30215)

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10.1111/j.1399-5618.2009.00680.x

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title = "No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No-go task: an fMRI study.",

abstract = "OBJECTIVES: It has been reported that one of the core features in patients with bipolar disorder II (BD II) is increased impulsivity. The aim of this study was to investigate whether patients with BD II showed decreased activation in the dorsal anterior cingulate cortex (dACC) as compared to healthy controls when performing a task sensitive to impulsivity.METHODS: Twenty-seven BD II patients and 28 healthy controls performed a Go/No-go task during a functional magnetic resonance imaging (fMRI) session. Eleven of the patients were unmedicated, and possible group differences between medicated and unmedicated patients were also assessed. Results: The groups did not differ in behavioral performance on the Go/No-go task. Both BD II subjects and healthy controls demonstrated dACC activity during the task, and analyses revealed no statistically significant group differences. Medicated and unmedicated patients also did not differ in the degree of fMRI activation.CONCLUSIONS: These findings do not support the hypothesis of abnormal dACC activity during a Go/No-go task in BD II patients.",

author = "Welander-Vatn, {Audun S} and Jimmy Jensen and Christine Lycke and Ingrid Agartz and Andres Server and Gadmar, {{\O}ystein Bech} and Ingrid Melle and Nakstad, {Per Hjalmar} and Andreassen, {Ole A}",

year = "2009",

doi = "10.1111/j.1399-5618.2009.00680.x",

language = "English",

volume = "11",

pages = "270--279",

journal = "Bipolar Disorders",

issn = "1398-5647",

publisher = "Blackwell Munksgaard",

number = "3",

}

TY - JOUR

T1 - No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No-go task

T2 - an fMRI study.

AU - Welander-Vatn, Audun S

AU - Jensen, Jimmy

AU - Lycke, Christine

AU - Agartz, Ingrid

AU - Server, Andres

AU - Gadmar, Øystein Bech

AU - Melle, Ingrid

AU - Nakstad, Per Hjalmar

AU - Andreassen, Ole A

PY - 2009

Y1 - 2009

N2 - OBJECTIVES: It has been reported that one of the core features in patients with bipolar disorder II (BD II) is increased impulsivity. The aim of this study was to investigate whether patients with BD II showed decreased activation in the dorsal anterior cingulate cortex (dACC) as compared to healthy controls when performing a task sensitive to impulsivity.METHODS: Twenty-seven BD II patients and 28 healthy controls performed a Go/No-go task during a functional magnetic resonance imaging (fMRI) session. Eleven of the patients were unmedicated, and possible group differences between medicated and unmedicated patients were also assessed. Results: The groups did not differ in behavioral performance on the Go/No-go task. Both BD II subjects and healthy controls demonstrated dACC activity during the task, and analyses revealed no statistically significant group differences. Medicated and unmedicated patients also did not differ in the degree of fMRI activation.CONCLUSIONS: These findings do not support the hypothesis of abnormal dACC activity during a Go/No-go task in BD II patients.

AB - OBJECTIVES: It has been reported that one of the core features in patients with bipolar disorder II (BD II) is increased impulsivity. The aim of this study was to investigate whether patients with BD II showed decreased activation in the dorsal anterior cingulate cortex (dACC) as compared to healthy controls when performing a task sensitive to impulsivity.METHODS: Twenty-seven BD II patients and 28 healthy controls performed a Go/No-go task during a functional magnetic resonance imaging (fMRI) session. Eleven of the patients were unmedicated, and possible group differences between medicated and unmedicated patients were also assessed. Results: The groups did not differ in behavioral performance on the Go/No-go task. Both BD II subjects and healthy controls demonstrated dACC activity during the task, and analyses revealed no statistically significant group differences. Medicated and unmedicated patients also did not differ in the degree of fMRI activation.CONCLUSIONS: These findings do not support the hypothesis of abnormal dACC activity during a Go/No-go task in BD II patients.

U2 - 10.1111/j.1399-5618.2009.00680.x

DO - 10.1111/j.1399-5618.2009.00680.x

M3 - Article

SN - 1398-5647

VL - 11

SP - 270

EP - 279

JO - Bipolar Disorders

JF - Bipolar Disorders

IS - 3

ER -

No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No-go task: an fMRI study.

Abstract

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