Periodontitis: a future risk of acute coronary syndrome?: A follow-up study over 3 years

Stefan Renvert, Ola Ohlsson, Thomas Pettersson, G. Rutger Persson

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    47 Citations (Scopus)


    Background: Periodontitis has been associated with cardiovascular disease. We assess if the recurrence of acute coronary syndrome (ACS) could be predicted by preceding medical and periodontal conditions. Methods: A total of 165 consecutive subjects with ACS and 159 medically healthy, matched control subjects were examined and followed for 3 years. Periodontitis was defined by alveolar bone loss. Subgingival microbial samples were studied by the checkerboard DNA-DNA hybridization method. Results: The recurrence of ACS was found in 66 of 165 (40.0%) subjects, and a first ACS event was found in seven of 159 (4.4%) subjects among baseline control subjects. Subjects who later had a second ACS event were older (P<0.001). Significantly higher serum levels of high-density lipoprotein (P <0.05), creatinine (P <0.01), and white blood cell (WBC) counts (P <0.001) were found in subjects with future ACS. Periodontitis was associated with a first event of ACS (crude odds ratio [OR]: 10.3:1; 95% confidence interval [CI]: 6.1 to 17.4; P <0.001) and the recurrence of ACS (crude OR: 3.6:1; 95% CI: 2.0 to 6.6; P <0.001). General linear modeling multivariate analysis, controlling for age and the prediction of a future ACS event, identified that WBC counts (F = 20.6; P <0.001), periodontitis (F = 17.6; P <0.001), and serum creatinine counts (F = 4.5; P<0.05) were explanatory of a future ACS event. Conclusions: The results of this study indicate that recurrent ACS events are predicted by serum WBC counts, serum creatinine levels, and a diagnosis of periodontitis. Significantly higher counts of putative pathogens are found in subjects with ACS, but these counts do not predict future ACS events.

    Original languageEnglish
    Pages (from-to)992-1000
    Number of pages8
    JournalJournal of Periodontology
    Issue number7
    Publication statusPublished - 2010

    Swedish Standard Keywords

    • Dentistry (30216)


    • Inflammation
    • acute myocardial-infarction
    • atherosclerosis
    • cardiovascular-disease risk
    • dna-dna hybridization
    • endothelial dysfunction
    • european-society
    • heart-disease
    • myocardial infarction
    • periodontitis
    • recurrence
    • serum inflammatory markers
    • systemic inflammation
    • therapy


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