Periodontitis related to cardiovascular events and mortality: a long-time longitudinal study

Viveca Wallin Bengtsson, Rutger G Persson, Johan Sanmartin Berglund, Stefan Renvert

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8 Citations (Scopus)
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OBJECTIVE: The present study assessed if individuals ≥ 60 years of age with periodontitis are more likely to develop stroke or ischemic heart diseases, or at a higher risk of death for 17 years.

MATERIAL AND METHODS: At baseline individuals ≥ 60 received a dental examination including a panoramic radiograph. Periodontitis was defined as having ≥ 30% sites with ≥ 5-mm distance from the cementoenamel junction to the marginal bone level. Medical records were annually reviewed from 2001 to 2018. Findings from the medical records identifying an ICD-10 code of stroke and ischemic heart diseases or death were registered.

RESULTS: Associations between periodontitis and incidence of ischemic heart disease were found in this 17-year follow-up study in all individuals 60-93 years (HR: 1.5, CI: 1.1-2.1, p = 0.017), in women (HR: 2.1, CI: 1.3-3.4, p = 0.002), and in individuals 78-96 years (HR: 1.7, CI: 1.0-2.6, p = 0.033). Periodontitis was associated with mortality in all individuals (HR: 1.4, CI: 1.2-1.8, p = 0.002), specifically in men (HR: 1.5, CI: 1.1-1.9, p = 0.006) or in ages 60-72 years (HR: 2.2, CI: 1.5-3.2, p = 0.000). Periodontitis was more prevalent among men (OR: 1.8, CI: 1.3-2.4, p = 0.000).

CONCLUSIONS: Individuals with periodontitis have an increased risk for future events of ischemic heart diseases and death.

CLINICAL RELEVANCE: Improving periodontal health in older individuals may reduce overall mortality and ischemic heart diseases. Both dental and medical professionals should be aware of the associations and ultimately cooperate.

Original languageEnglish
Pages (from-to)4085-4095
Number of pages11
JournalClinical Oral Investigations
Early online date2021
Publication statusPublished - 2021

Swedish Standard Keywords

  • Dentistry (30216)


  • Epidemiology
  • Ischemic heart disease
  • Mortality
  • Periodontitis
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Risk Factors
  • Male
  • Periodontitis/complications
  • Incidence
  • Adolescent
  • Female
  • Stroke/epidemiology
  • Aged
  • Longitudinal Studies


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