Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.

Frank A Roberts; Laura S Houston; Sheila A Lukehart; Lloyd A Mancl; G. Rutger Persson; Roy C Page

doi:10.1128/IAI.72.2.1166-1168.2004

Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.

Frank A Roberts, Laura S Houston, Sheila A Lukehart, Lloyd A Mancl, G. Rutger Persson, Roy C Page

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Interleukin-1beta, tumor necrosis factor alpha, prostaglandin E2 (PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE2 levels were dramatically suppressed (P < 0.0001) in immunized animals versus controls. A significant correlation (P < 0.027) was also found between PGE2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2 in periodontal destruction.

Original language	English
Pages (from-to)	1166-1168
Number of pages	2
Journal	Infection and Immunity
Volume	72
Issue number	2
DOIs	https://doi.org/10.1128/IAI.72.2.1166-1168.2004
Publication status	Published - 2004
Externally published	Yes

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Dentistry (30216)

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10.1128/IAI.72.2.1166-1168.2004

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title = "Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.",

abstract = "Interleukin-1beta, tumor necrosis factor alpha, prostaglandin E2 (PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE2 levels were dramatically suppressed (P < 0.0001) in immunized animals versus controls. A significant correlation (P < 0.027) was also found between PGE2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2 in periodontal destruction.",

author = "Roberts, {Frank A} and Houston, {Laura S} and Lukehart, {Sheila A} and Mancl, {Lloyd A} and Persson, {G. Rutger} and Page, {Roy C}",

year = "2004",

doi = "10.1128/IAI.72.2.1166-1168.2004",

language = "English",

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pages = "1166--1168",

journal = "Infection and Immunity",

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publisher = "American Society for Microbiology",

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T1 - Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.

AU - Roberts, Frank A

AU - Houston, Laura S

AU - Lukehart, Sheila A

AU - Mancl, Lloyd A

AU - Persson, G. Rutger

AU - Page, Roy C

PY - 2004

Y1 - 2004

N2 - Interleukin-1beta, tumor necrosis factor alpha, prostaglandin E2 (PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE2 levels were dramatically suppressed (P < 0.0001) in immunized animals versus controls. A significant correlation (P < 0.027) was also found between PGE2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2 in periodontal destruction.

AB - Interleukin-1beta, tumor necrosis factor alpha, prostaglandin E2 (PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE2 levels were dramatically suppressed (P < 0.0001) in immunized animals versus controls. A significant correlation (P < 0.027) was also found between PGE2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2 in periodontal destruction.

U2 - 10.1128/IAI.72.2.1166-1168.2004

DO - 10.1128/IAI.72.2.1166-1168.2004

M3 - Article

SN - 0019-9567

VL - 72

SP - 1166

EP - 1168

JO - Infection and Immunity

JF - Infection and Immunity

IS - 2

ER -

Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.

Abstract

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UN SDGs

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