Platelet activation in hemolytic uremic syndrome

D Karpman, M Manea, Fariba Vaziri-Sani, A L Stahl, A C Kristoffersson

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Platelet consumption in platelet-fibrin aggregates leading to thrombocytopenia and small vessel obstruction are major features of the hemolytic uremic syndrome (HUS). Although thrombocytopenia has been correlated to poor prognosis, the mechanisms by which thrombocytopenia develops in HUS have not been completely elucidated. However, plausible explanations have been platelet contact with thrombogenic surfaces and/or direct contact with an aggregating agent. This article summarizes several mechanisms of platelet activation, interactions with leukocytes, chemokine release, complement activation, and antimicrobial defense. Specific mechanisms are outlined by which platelets may be activated, leading to thrombocytopenia during HUS. In diarrhea-associated HUS Shiga toxin has been shown to injure the endothelium, thus exposing the subendothelium, releasing tissue factor, and rendering the vessel wall prothrombotic. Shiga toxin also binds to and activates platelets. The toxin may activate endothelial cells and platelets simultaneously. In atypical HUS the alternative complement pathway is activated because of mutations in complement regulatory proteins. Mutated factor H does not bind to endothelium and platelets efficiently, enabling complement activation on these cells. In thrombotic thrombocytopenic purpura, intravascular platelet clotting Occurs due to dysfunction of the von Willebrand factor (VWF)-cleaving protease ADAMTS13. Thrombi are formed by binding of platelets to ultralarge VWF multimers.

Original languageEnglish
Pages (from-to)128-145
Number of pages17
JournalSeminars in Thrombosis and Hemostasis
Volume32
Issue number2
DOIs
Publication statusPublished - 2006
Externally publishedYes

Swedish Standard Keywords

  • Cell and Molecular Biology (30108)
  • Immunology in the medical area (30110)

Keywords

  • Shiga toxin
  • complement
  • enterohaemorrhagic Escherichia coli
  • haemolytic uraemic syndrome
  • microvesicles

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