An Epitope-Imprinted Biointerface with Dynamic Bioactivity for Modulating Cell–Biomaterial Interactions

Guoqing Pan, Sudhirkumar Shinde, Sing Yee Yeung, Miglė Jakštaitė, Qianjin Li, Anette Gjörloff Wingren, Börje Sellergren

Forskningsoutput: TidskriftsbidragArtikelPeer review

110 Citeringar (Scopus)

Sammanfattning

In this study, an epitope-imprinting strategy was employed for the dynamic display of bioactive ligands on a material interface. An imprinted surface was initially designed to exhibit specific affinity towards a short peptide (i.e., the epitope). This surface was subsequently used to anchor an epitope-tagged cell-adhesive peptide ligand (RGD: Arg-Gly-Asp). Owing to reversible epitope-binding affinity, ligand presentation and thereby cell adhesion could be controlled. As compared to current strategies for the fabrication of dynamic biointerfaces, for example, through reversible covalent or host–guest interactions, such a molecularly tunable dynamic system based on a surface-imprinting process may unlock new applications in in situ cell biology, diagnostics, and regenerative medicine.

OriginalspråkEngelska
Sidor (från-till)15959-15963
Antal sidor5
TidskriftAngewandte Chemie - International Edition
Volym56
Nummer50
DOI
StatusPublicerad - 2017-dec.-28
Externt publiceradJa

Nationell ämneskategori

  • Medicinsk bioteknologi (304)

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