Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer

Leon. J. Brokken, Yvonne Lundberg-Giwercman, Ewa Rajpert De-Meyts, Jakob Eberhard, Olof Ståhl, Gabriella Cohn-Cedermark, Gedske Daugaard, Stefan Arver, Aleksandr Giwercman

Forskningsoutput: TidskriftsbidragArtikelPeer review

18 Citeringar (Scopus)

Sammanfattning

Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR (rs7371084) were predictors of higher LH levels and higher androgen sensitivity index in healthy subjects. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis.
OriginalspråkEngelska
Sidor (från-till)279-285
Antal sidor7
TidskriftMolecular and Cellular Endocrinology
Volym351
Utgåva2
DOI
StatusPublicerad - 2012
Externt publiceradJa

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  • Endokrinologi och diabetes (30205)

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