Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease

P Brundin, O Pogarell, Peter Hagell, P Piccini, H Widner, A Schrag, A Kupsch, L Crabb, P Odin, B Gustavii, A Björklund, D J Brooks, C D Marsden, W H Oertel, N P Quinn, S Rehncrona, O Lindvall

Forskningsoutput: TidskriftsbidragArtikelPeer review

242 Citeringar (Scopus)

Sammanfattning

Five parkinsonian patients were transplanted bilaterally into the putamen and caudate nucleus with human embryonic mesencephalic tissue from between seven and nine donors. To increase graft survival, the lipid peroxidation inhibitor tirilazad mesylate was administered to the tissue before implantation and intravenously to the patients for 3 days thereafter. During the second postoperative year, the mean daily L-dopa dose was reduced by 54% and the UPDRS (Unified Parkinson's Disease Rating Scale) motor score in 'off' phase was reduced by a mean of 40%. At 10-23 months after grafting, PET showed a mean 61% increase of 6-L-[(18)F]fluorodopa uptake in the putamen, and 24% increase in the caudate nucleus, compared with preoperative values. No obvious differences in the pattern of motor recovery were observed between these and other previously studied cases with putamen grafts alone. The amount of mesencephalic tissue implanted in each putamen and caudate nucleus was 42 and 50% lower, respectively, compared with previously transplanted patients from our centre. Despite this reduction in grafted tissue, the magnitudes of symptomatic relief and graft survival were very similar. These findings suggest that tirilazad mesylate may improve survival of grafted dopamine neurons in patients, which is in agreement with observations in experimental animals.

OriginalspråkEngelska
Sidor (från-till)1380-1390
Antal sidor10
TidskriftBrain
Volym123
Utgåva7
DOI
StatusPublicerad - 2000
Externt publiceradJa

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  • Medicin och hälsovetenskap (3)

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