TY - JOUR
T1 - Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition
AU - Obón-Santacana, Mireia
AU - Luján-Barroso, Leila
AU - Freisling, Heinz
AU - Naudin, Sabine
AU - Boutron-Ruault, Marie-Christine
AU - Mancini, Francesca Romana
AU - Rebours, Vinciane
AU - Kühn, Tilman
AU - Katzke, Verena
AU - Boeing, Heiner
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Overvad, Kim
AU - Lasheras, Cristina
AU - Rodríguez-Barranco, Miguel
AU - Amiano, Pilar
AU - Santiuste, Carmen
AU - Ardanaz, Eva
AU - Khaw, Kay-Thee
AU - Wareham, Nicholas J
AU - Schmidt, Julie A
AU - Aune, Dagfinn
AU - Trichopoulou, Antonia
AU - Thriskos, Paschalis
AU - Peppa, Eleni
AU - Masala, Giovanna
AU - Grioni, Sara
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Bueno-de-Mesquita, Bas
AU - Sciannameo, Veronica
AU - Vermeulen, Roel
AU - Sonestedt, Emily
AU - Sund, Malin
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - González, Carlos A
AU - Riboli, Elio
AU - Duell, Eric J
N1 - © 2019 UICC.
PY - 2019
Y1 - 2019
N2 - Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
AB - Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
KW - Carcinoma, Pancreatic Ductal/etiology
KW - Diet
KW - Europe
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Nuts
KW - Pancreatic Neoplasms/etiology
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Risk Factors
KW - Seeds
KW - Surveys and Questionnaires
U2 - 10.1002/ijc.32415
DO - 10.1002/ijc.32415
M3 - Article
C2 - 31107546
SN - 0020-7136
VL - 146
SP - 76
EP - 84
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 1
ER -
