Determination of thirteen antibiotics in drug products: a new LC-MS/MS tool for screening drug product quality

Samuel Oppong Bekoe, Søren Alex Bak, Erland Björklund, Kristine A. Krogh, Nathaniel N. N. A. Okine, Reimmiel K. Adosraku, Bjarne Styrishave, Martin Hansen

Forskningsoutput: TidskriftsbidragArtikelPeer review

Sammanfattning

Poor quality antibiotic medicines in circulation in Sub-Saharan Africa continue to be a burden. Pharmaceutical trade in substandard and counterfeit medicines is on the rise. The chemical quality of antibiotics dispensed in health facilities and recognised drug outlets in Ghana, when compromised, could be a major drawback to efforts made in fighting antibiotic resistance globally. To improve on antibiotic drug quality monitoring, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology, which is capable of quantifying thirteen antibiotics in drug products, was developed and validated in present work. The methodology was applied to various drug products including tablets, capsules, suspensions, syrups, intravenous and injection solutions as well as ear and eye droplets used as essential medicines in a Sub-Saharan country, Ghana.

OriginalspråkEngelska
Sidor (från-till)5847-5855
Antal sidor8
TidskriftAnalytical Methods
Volym6
DOI
StatusPublicerad - 2014

Nationell ämneskategori

  • Analytisk kemi (10401)

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