TY - JOUR
T1 - Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality
T2 - EPIC cohort study in 9 European countries
AU - Fiolet, Thibault
AU - Nicolas, Geneviève
AU - Casagrande, Corinne
AU - Horvath, Zsuzsanna
AU - Frenoy, Pauline
AU - Weiderpass, Elisabete
AU - Gunter, Marc J
AU - Manjer, Jonas
AU - Sonestedt, Emily
AU - Palli, Domenico
AU - Simeon, Vittorio
AU - Tumino, Rosario
AU - Bueno-de-Mesquita, Bas
AU - Huerta, José María
AU - Rodriguez-Barranco, Miguel
AU - Abilleira, Eunate
AU - Sacerdote, Carlotta
AU - Schulze, Matthias B
AU - Heath, Alicia K
AU - Rylander, Charlotta
AU - Skeie, Guri
AU - Nøst, Therese Haugdahl
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Pala, Valeria
AU - Kvaskoff, Marina
AU - Huybrechts, Inge
AU - Mancini, Francesca Romana
N1 - Copyright © 2023 Elsevier GmbH. All rights reserved.
PY - 2023/11/20
Y1 - 2023/11/20
N2 - Dioxins and polychlorinated biphenyls (PCBs) are toxic, endocrine disruptors and persistent chemicals for which the main exposure source is diet due to their bioaccumulation and biomagnification in food chains. Cohort studies in the general populations have reported inconsistent associations between these chemicals in serum/plasma and mortality. Our objective was to study the association between dietary intake of 17 dioxins and 35 PCBs and all-cause, cancer-specific and cardiovascular-specific mortalities were assessed in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with European food contamination data provided by the European Food Safety Authority. We applied multivariable Cox regressions. The analysis included 451,390 adults (mean ± SD age:51.1 ± 9.7 years) with 46,627 deaths and a median follow-up of 17.4 years (IQR = 15.2-19.1). A U-shaped non-linear association with all-cause mortality for dietary intake of dioxins (Pnon-linearity<0.0001), DL-PCB (Pnon-linearity = 0.0001), and NDL-PCBs (Pnon-linearity<0.01) was observed. For example, the hazard ratios (95%Confidance interval) for all-cause mortality obtained with the spline model was equal to 1.03 (1.02-1.05) for low levels of intake to dioxins (7 pg TEQ/day), 0.93 (0.90-0.96) for moderate levels of intake (25 pg TEQ/day), while for high levels of intake (55 pg TEQ/day) it was 1.03 (0.97-1.09). Intake of dioxins, DL-PCBs and NDL-PCBs was not associated with cardiovascular mortality. There was no association between intakes of dioxins and cancer mortality, but a U-shaped association was observed for intake of DL-PCBs and intakes of NDL-PCBs and cancer mortality. The PCBs and dioxins are known to have endocrine disrupting properties which can lead to non-monotonic dose responses. These results need to be interpreted with caution and further studies are needed to better clarify the association between dietary intake of dioxins and PCB and mortality in the general population.
AB - Dioxins and polychlorinated biphenyls (PCBs) are toxic, endocrine disruptors and persistent chemicals for which the main exposure source is diet due to their bioaccumulation and biomagnification in food chains. Cohort studies in the general populations have reported inconsistent associations between these chemicals in serum/plasma and mortality. Our objective was to study the association between dietary intake of 17 dioxins and 35 PCBs and all-cause, cancer-specific and cardiovascular-specific mortalities were assessed in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with European food contamination data provided by the European Food Safety Authority. We applied multivariable Cox regressions. The analysis included 451,390 adults (mean ± SD age:51.1 ± 9.7 years) with 46,627 deaths and a median follow-up of 17.4 years (IQR = 15.2-19.1). A U-shaped non-linear association with all-cause mortality for dietary intake of dioxins (Pnon-linearity<0.0001), DL-PCB (Pnon-linearity = 0.0001), and NDL-PCBs (Pnon-linearity<0.01) was observed. For example, the hazard ratios (95%Confidance interval) for all-cause mortality obtained with the spline model was equal to 1.03 (1.02-1.05) for low levels of intake to dioxins (7 pg TEQ/day), 0.93 (0.90-0.96) for moderate levels of intake (25 pg TEQ/day), while for high levels of intake (55 pg TEQ/day) it was 1.03 (0.97-1.09). Intake of dioxins, DL-PCBs and NDL-PCBs was not associated with cardiovascular mortality. There was no association between intakes of dioxins and cancer mortality, but a U-shaped association was observed for intake of DL-PCBs and intakes of NDL-PCBs and cancer mortality. The PCBs and dioxins are known to have endocrine disrupting properties which can lead to non-monotonic dose responses. These results need to be interpreted with caution and further studies are needed to better clarify the association between dietary intake of dioxins and PCB and mortality in the general population.
KW - Adult
KW - Humans
KW - Middle Aged
KW - Polychlorinated Biphenyls/analysis
KW - Dioxins/analysis
KW - Cohort Studies
KW - Prospective Studies
KW - Eating
KW - Food Contamination/analysis
KW - Neoplasms
U2 - 10.1016/j.ijheh.2023.114287
DO - 10.1016/j.ijheh.2023.114287
M3 - Article
C2 - 37989047
SN - 1438-4639
VL - 255
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
M1 - 114287
ER -
