Dyskinesias following neural transplantation in Parkinson's disease.

Peter Hagell, Paola Piccini, Anders Björklund, Patrik Brundin, Stig Rehncrona, Håkan Widner, Lesley Crabb, Nicola Pavese, Wolfgang H Oertel, Niall Quinn, David J Brooks, Olle Lindvall

Forskningsoutput: TidskriftsbidragArtikelPeer review

367 Citeringar (Scopus)

Sammanfattning

Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.

OriginalspråkEngelska
Sidor (från-till)627-628
Antal sidor1
TidskriftNature Neuroscience
Volym5
Utgåva7
DOI
StatusPublicerad - 2002
Externt publiceradJa

Nationell ämneskategori

  • Klinisk medicin (302)

Fingeravtryck

Fördjupa i forskningsämnen för ”Dyskinesias following neural transplantation in Parkinson's disease.”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här