@article{afa2f03c849f4fccbc1f910a19505746,
title = "Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia",
abstract = "PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.",
keywords = "Pediatric leukemia, PTEN, SHP1, Tissue microarray",
author = "Fredrika Gauffin and Eva Diffner and Britt Gustafsson and Ann Nordgren and Wingren, {Anette Gjorloff} and Birgitta Sander and Persson, {Jenny Liao} and Britt Gustafsson",
note = "Funding Information: The authors thank Elise Nilsson and Birgitta Axelsson for invaluable technical assistance and Jan Kowalski, biostatistical analyzer, Karolinska Institutet. This study was supported by grants from the Government Public Health Grant, Karolinska University Hospital CALF, and Mary B{\'e}ve Foundation for Pediatric Cancer Research, The Swedish Children Cancer Foundation, The Samariten Foundation, The Swedish Cancer Society, Malm{\"o} Cancer Foundation, Crafoord Foundation, Malm{\"o} Hospital Foundation, and Lund University Medical Faculty Grant.",
year = "2009",
month = jan,
doi = "10.1080/08880010802625530",
language = "English",
volume = "26",
pages = "48--56",
journal = "Pediatric Hematology and Oncology",
issn = "0888-0018",
publisher = "Informa Healthcare",
number = "1",
}