TY - JOUR
T1 - Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort
AU - Molina-Montes, Esther
AU - Sánchez, María-José
AU - Zamora-Ros, Raul
AU - Bueno-de-Mesquita, H B As
AU - Wark, Petra A
AU - Obon-Santacana, Mireia
AU - Kühn, Tilman
AU - Katzke, Verena
AU - Travis, Ruth C
AU - Ye, Weimin
AU - Sund, Malin
AU - Naccarati, Alessio
AU - Mattiello, Amalia
AU - Krogh, Vittorio
AU - Martorana, Caterina
AU - Masala, Giovanna
AU - Amiano, Pilar
AU - Huerta, José-María
AU - Barricarte, Aurelio
AU - Quirós, José-Ramón
AU - Weiderpass, Elisabete
AU - Angell Åsli, Lene
AU - Skeie, Guri
AU - Ericson, Ulrika
AU - Sonestedt, Emily
AU - Peeters, Petra H
AU - Romieu, Isabelle
AU - Scalbert, Augustin
AU - Overvad, Kim
AU - Clemens, Matthias
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Peppa, Eleni
AU - Vidalis, Pavlos
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Boutroun-Rualt, Marie-Christine
AU - Clavel-Chapelon, Françoise
AU - Cross, Amanda J
AU - Lu, Yunxia
AU - Riboli, Elio
AU - Duell, Eric J
N1 - © 2016 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95-1.11 and 1.02; 95% CI: 0.89-1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91-1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.
AB - Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95-1.11 and 1.02; 95% CI: 0.89-1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91-1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.
KW - Cohort Studies
KW - Diet/statistics & numerical data
KW - Diet Records
KW - Europe/epidemiology
KW - Female
KW - Flavonoids/administration & dosage
KW - Humans
KW - Life Style
KW - Lignans/administration & dosage
KW - Male
KW - Middle Aged
KW - Pancreatic Neoplasms/epidemiology
KW - Proportional Hazards Models
KW - Prospective Studies
U2 - 10.1002/ijc.30190
DO - 10.1002/ijc.30190
M3 - Article
C2 - 27184434
SN - 0020-7136
VL - 139
SP - 1480
EP - 1492
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 7
ER -
