TY - JOUR
T1 - Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer
T2 - A Prospective Analysis of the EPIC Study
AU - Almanza-Aguilera, Enrique
AU - Guiñón-Fort, Daniel
AU - Perez-Cornago, Aurora
AU - Martínez-Huélamo, Miriam
AU - Andrés-Lacueva, Cristina
AU - Tjønneland, Anne
AU - Eriksen, Anne Kirstine
AU - Katzke, Verena
AU - Bajracharya, Rashmita
AU - Schulze, Matthias B
AU - Masala, Giovanna
AU - Oliverio, Andreina
AU - Tumino, Rosario
AU - Manfredi, Luca
AU - Lasheras, Cristina
AU - Crous-Bou, Marta
AU - Sánchez, Maria-José
AU - Amiano, Pilar
AU - Colorado-Yohar, Sandra M
AU - Guevara, Marcela
AU - Sonestedt, Emily
AU - Bjartell, Anders
AU - Thysell, Elin
AU - Weiderpass, Elisabete
AU - Aune, Dagfinn
AU - Aglago, Elom K
AU - Travis, Ruth C
AU - Zamora-Ros, Raul
PY - 2023/8/11
Y1 - 2023/8/11
N2 - Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94-1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.
AB - Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94-1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.
U2 - 10.3390/cancers15164067
DO - 10.3390/cancers15164067
M3 - Article
C2 - 37627095
SN - 2072-6694
VL - 15
JO - Cancers
JF - Cancers
IS - 16
M1 - 4067
ER -
