Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

Jia-Yi Li; Elisabet Englund; Janice L. Holton; Denis Soulet; Peter Hagell; Andrew J. Lees; Tammaryn Lashley; Niall P Quinn; Stig Rehncrona; Anders Björklund; Håkan Widner; Tamas Revesz; Olle Lindvall; Patrik Brundin

doi:10.1038/nm1746

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

Jia-Yi Li, Elisabet Englund, Janice L. Holton, Denis Soulet, Peter Hagell, Andrew J. Lees, Tammaryn Lashley, Niall P Quinn, Stig Rehncrona, Anders Björklund, Håkan Widner, Tamas Revesz, Olle Lindvall, Patrik Brundin

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Sammanfattning

Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

Originalspråk	Engelska
Sidor (från-till)	501-503
Antal sidor	2
Tidskrift	Nature Medicine
Volym	14
Nummer	5
DOI	https://doi.org/10.1038/nm1746
Status	Publicerad - 2008
Externt publicerad	Ja

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Neurologi (30207)

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10.1038/nm1746

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title = "Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation",

abstract = "Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.",

author = "Jia-Yi Li and Elisabet Englund and Holton, {Janice L.} and Denis Soulet and Peter Hagell and Lees, {Andrew J.} and Tammaryn Lashley and Quinn, {Niall P} and Stig Rehncrona and Anders Bj{\"o}rklund and H{\aa}kan Widner and Tamas Revesz and Olle Lindvall and Patrik Brundin",

year = "2008",

doi = "10.1038/nm1746",

language = "English",

volume = "14",

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journal = "Nature Medicine",

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T1 - Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

AU - Li, Jia-Yi

AU - Englund, Elisabet

AU - Holton, Janice L.

AU - Soulet, Denis

AU - Hagell, Peter

AU - Lees, Andrew J.

AU - Lashley, Tammaryn

AU - Quinn, Niall P

AU - Rehncrona, Stig

AU - Björklund, Anders

AU - Widner, Håkan

AU - Revesz, Tamas

AU - Lindvall, Olle

AU - Brundin, Patrik

PY - 2008

Y1 - 2008

N2 - Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

AB - Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

U2 - 10.1038/nm1746

DO - 10.1038/nm1746

M3 - Article

SN - 1546-170X

VL - 14

SP - 501

EP - 503

JO - Nature Medicine

JF - Nature Medicine

IS - 5

ER -

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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