Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

Jia-Yi Li, Elisabet Englund, Janice L. Holton, Denis Soulet, Peter Hagell, Andrew J. Lees, Tammaryn Lashley, Niall P Quinn, Stig Rehncrona, Anders Björklund, Håkan Widner, Tamas Revesz, Olle Lindvall, Patrik Brundin

Forskningsoutput: TidskriftsbidragArtikelPeer review

1218 Citeringar (Scopus)

Sammanfattning

Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

OriginalspråkEngelska
Sidor (från-till)501-503
Antal sidor2
TidskriftNature Medicine
Volym14
Utgåva5
DOI
StatusPublicerad - 2008
Externt publiceradJa

Nationell ämneskategori

  • Neurologi (30207)

Fingeravtryck

Fördjupa i forskningsämnen för ”Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här