No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No-go task: an fMRI study.

Audun S Welander-Vatn, Jimmy Jensen, Christine Lycke, Ingrid Agartz, Andres Server, Øystein Bech Gadmar, Ingrid Melle, Per Hjalmar Nakstad, Ole A Andreassen

Forskningsoutput: TidskriftsbidragArtikelPeer review

21 Citeringar (Scopus)

Sammanfattning

OBJECTIVES: It has been reported that one of the core features in patients with bipolar disorder II (BD II) is increased impulsivity. The aim of this study was to investigate whether patients with BD II showed decreased activation in the dorsal anterior cingulate cortex (dACC) as compared to healthy controls when performing a task sensitive to impulsivity.

METHODS: Twenty-seven BD II patients and 28 healthy controls performed a Go/No-go task during a functional magnetic resonance imaging (fMRI) session. Eleven of the patients were unmedicated, and possible group differences between medicated and unmedicated patients were also assessed. Results: The groups did not differ in behavioral performance on the Go/No-go task. Both BD II subjects and healthy controls demonstrated dACC activity during the task, and analyses revealed no statistically significant group differences. Medicated and unmedicated patients also did not differ in the degree of fMRI activation.

CONCLUSIONS: These findings do not support the hypothesis of abnormal dACC activity during a Go/No-go task in BD II patients.

OriginalspråkEngelska
Sidor (från-till)270-279
Antal sidor9
TidskriftBipolar Disorders
Volym11
Utgåva3
DOI
StatusPublicerad - 2009
Externt publiceradJa

Nationell ämneskategori

  • Neurovetenskaper (30105)
  • Psykiatri (30215)

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