TY - JOUR
T1 - Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study
AU - Merritt, Melissa A
AU - Tzoulaki, Ioanna
AU - van den Brandt, Piet A
AU - Schouten, Leo J
AU - Tsilidis, Konstantinos K
AU - Weiderpass, Elisabete
AU - Patel, Chirag J
AU - Tjønneland, Anne
AU - Hansen, Louise
AU - Overvad, Kim
AU - His, Mathilde
AU - Dartois, Laureen
AU - Boutron-Ruault, Marie-Christine
AU - Fortner, Renée T
AU - Kaaks, Rudolf
AU - Aleksandrova, Krasimira
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Bamia, Christina
AU - Palli, Domenico
AU - Krogh, Vittorio
AU - Tumino, Rosario
AU - Ricceri, Fulvio
AU - Mattiello, Amalia
AU - Bueno-de-Mesquita, H Bas
AU - Onland-Moret, N Charlotte
AU - Peeters, Petra H
AU - Skeie, Guri
AU - Jareid, Mie
AU - Quirós, J Ramón
AU - Obón-Santacana, Mireia
AU - Sánchez, María-José
AU - Chamosa, Saioa
AU - Huerta, José M
AU - Barricarte, Aurelio
AU - Dias, Joana A
AU - Sonestedt, Emily
AU - Idahl, Annika
AU - Lundin, Eva
AU - Wareham, Nicholas J
AU - Khaw, Kay-Tee
AU - Travis, Ruth C
AU - Ferrari, Pietro
AU - Riboli, Elio
AU - Gunter, Marc J
N1 - © 2016 American Society for Nutrition.
PY - 2016/1
Y1 - 2016/1
N2 - BACKGROUND: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.DESIGN: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).CONCLUSION: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.
AB - BACKGROUND: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.DESIGN: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).CONCLUSION: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.
KW - Adult
KW - Aged
KW - Carcinoma, Ovarian Epithelial
KW - Cohort Studies
KW - Diet/adverse effects
KW - Dietary Fats/adverse effects
KW - Fatty Acids/adverse effects
KW - Feeding Behavior
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Neoplasms, Glandular and Epithelial/etiology
KW - Netherlands
KW - Ovarian Neoplasms/etiology
KW - Risk Factors
U2 - 10.3945/ajcn.115.118588
DO - 10.3945/ajcn.115.118588
M3 - Article
C2 - 26607939
SN - 0002-9165
VL - 103
SP - 161
EP - 167
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 1
ER -