Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Melissa A Merritt; Ioanna Tzoulaki; Piet A van den Brandt; Leo J Schouten; Konstantinos K Tsilidis; Elisabete Weiderpass; Chirag J Patel; Anne Tjønneland; Louise Hansen; Kim Overvad; Mathilde His; Laureen Dartois; Marie-Christine Boutron-Ruault; Renée T Fortner; Rudolf Kaaks; Krasimira Aleksandrova; Heiner Boeing; Antonia Trichopoulou; Pagona Lagiou; Christina Bamia; Domenico Palli; Vittorio Krogh; Rosario Tumino; Fulvio Ricceri; Amalia Mattiello; H Bas Bueno-de-Mesquita; N Charlotte Onland-Moret; Petra H Peeters; Guri Skeie; Mie Jareid; J Ramón Quirós; Mireia Obón-Santacana; María-José Sánchez; Saioa Chamosa; José M Huerta; Aurelio Barricarte; Joana A Dias; Emily Sonestedt; Annika Idahl; Eva Lundin; Nicholas J Wareham; Kay-Tee Khaw; Ruth C Travis; Pietro Ferrari; Elio Riboli; Marc J Gunter

doi:10.3945/ajcn.115.118588

Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Melissa A Merritt, Ioanna Tzoulaki, Piet A van den Brandt, Leo J Schouten, Konstantinos K Tsilidis, Elisabete Weiderpass, Chirag J Patel, Anne Tjønneland, Louise Hansen, Kim Overvad, Mathilde His, Laureen Dartois, Marie-Christine Boutron-Ruault, Renée T Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Christina BamiaDomenico Palli, Vittorio Krogh, Rosario Tumino, Fulvio Ricceri, Amalia Mattiello, H Bas Bueno-de-Mesquita, N Charlotte Onland-Moret, Petra H Peeters, Guri Skeie, Mie Jareid, J Ramón Quirós, Mireia Obón-Santacana, María-José Sánchez, Saioa Chamosa, José M Huerta, Aurelio Barricarte, Joana A Dias, Emily Sonestedt, Annika Idahl, Eva Lundin, Nicholas J Wareham, Kay-Tee Khaw, Ruth C Travis, Pietro Ferrari, Elio Riboli, Marc J Gunter

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30 Citeringar (Scopus)

Sammanfattning

BACKGROUND: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.

OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.

DESIGN: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.

RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).

CONCLUSION: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.

Originalspråk	Engelska
Sidor (från-till)	161-7
Antal sidor	7
Tidskrift	American Journal of Clinical Nutrition
Volym	103
Nummer	1
DOI	https://doi.org/10.3945/ajcn.115.118588
Status	Publicerad - 2016-jan.
Externt publicerad	Ja

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Merritt, M. A., Tzoulaki, I., van den Brandt, P. A., Schouten, L. J., Tsilidis, K. K., Weiderpass, E., Patel, C. J., Tjønneland, A., Hansen, L., Overvad, K., His, M., Dartois, L., Boutron-Ruault, M.-C., Fortner, R. T., Kaaks, R., Aleksandrova, K., Boeing, H., Trichopoulou, A., Lagiou, P., ... Gunter, M. J. (2016). Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. American Journal of Clinical Nutrition, 103(1), 161-7. https://doi.org/10.3945/ajcn.115.118588

@article{6e144e46530f439399213bc352e7995d,

title = "Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study",

abstract = "BACKGROUND: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.DESIGN: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).CONCLUSION: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.",

keywords = "Adult, Aged, Carcinoma, Ovarian Epithelial, Cohort Studies, Diet/adverse effects, Dietary Fats/adverse effects, Fatty Acids/adverse effects, Feeding Behavior, Female, Humans, Male, Middle Aged, Neoplasms, Glandular and Epithelial/etiology, Netherlands, Ovarian Neoplasms/etiology, Risk Factors",

author = "Merritt, {Melissa A} and Ioanna Tzoulaki and {van den Brandt}, {Piet A} and Schouten, {Leo J} and Tsilidis, {Konstantinos K} and Elisabete Weiderpass and Patel, {Chirag J} and Anne Tj{\o}nneland and Louise Hansen and Kim Overvad and Mathilde His and Laureen Dartois and Marie-Christine Boutron-Ruault and Fortner, {Ren{\'e}e T} and Rudolf Kaaks and Krasimira Aleksandrova and Heiner Boeing and Antonia Trichopoulou and Pagona Lagiou and Christina Bamia and Domenico Palli and Vittorio Krogh and Rosario Tumino and Fulvio Ricceri and Amalia Mattiello and Bueno-de-Mesquita, {H Bas} and Onland-Moret, {N Charlotte} and Peeters, {Petra H} and Guri Skeie and Mie Jareid and Quir{\'o}s, {J Ram{\'o}n} and Mireia Ob{\'o}n-Santacana and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Saioa Chamosa and Huerta, {Jos{\'e} M} and Aurelio Barricarte and Dias, {Joana A} and Emily Sonestedt and Annika Idahl and Eva Lundin and Wareham, {Nicholas J} and Kay-Tee Khaw and Travis, {Ruth C} and Pietro Ferrari and Elio Riboli and Gunter, {Marc J}",

note = "{\textcopyright} 2016 American Society for Nutrition.",

year = "2016",

month = jan,

doi = "10.3945/ajcn.115.118588",

language = "English",

volume = "103",

pages = "161--7",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "Elsevier B.V.",

number = "1",

}

Merritt, MA, Tzoulaki, I, van den Brandt, PA, Schouten, LJ, Tsilidis, KK, Weiderpass, E, Patel, CJ, Tjønneland, A, Hansen, L, Overvad, K, His, M, Dartois, L, Boutron-Ruault, M-C, Fortner, RT, Kaaks, R, Aleksandrova, K, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Palli, D, Krogh, V, Tumino, R, Ricceri, F, Mattiello, A, Bueno-de-Mesquita, HB, Onland-Moret, NC, Peeters, PH, Skeie, G, Jareid, M, Quirós, JR, Obón-Santacana, M, Sánchez, M-J, Chamosa, S, Huerta, JM, Barricarte, A, Dias, JA, Sonestedt, E, Idahl, A, Lundin, E, Wareham, NJ, Khaw, K-T, Travis, RC, Ferrari, P, Riboli, E & Gunter, MJ 2016, 'Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study', American Journal of Clinical Nutrition, vol. 103, nr. 1, s. 161-7. https://doi.org/10.3945/ajcn.115.118588

Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. / Merritt, Melissa A; Tzoulaki, Ioanna; van den Brandt, Piet A et al.
I: American Journal of Clinical Nutrition, Vol. 103, Nr. 1, 01.2016, s. 161-7.

Forskningsoutput: Tidskriftsbidrag › Artikel › Peer review

TY - JOUR

T1 - Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

AU - Merritt, Melissa A

AU - Tzoulaki, Ioanna

AU - van den Brandt, Piet A

AU - Schouten, Leo J

AU - Tsilidis, Konstantinos K

AU - Weiderpass, Elisabete

AU - Patel, Chirag J

AU - Tjønneland, Anne

AU - Hansen, Louise

AU - Overvad, Kim

AU - His, Mathilde

AU - Dartois, Laureen

AU - Boutron-Ruault, Marie-Christine

AU - Fortner, Renée T

AU - Kaaks, Rudolf

AU - Aleksandrova, Krasimira

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Bamia, Christina

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Mattiello, Amalia

AU - Bueno-de-Mesquita, H Bas

AU - Onland-Moret, N Charlotte

AU - Peeters, Petra H

AU - Skeie, Guri

AU - Jareid, Mie

AU - Quirós, J Ramón

AU - Obón-Santacana, Mireia

AU - Sánchez, María-José

AU - Chamosa, Saioa

AU - Huerta, José M

AU - Barricarte, Aurelio

AU - Dias, Joana A

AU - Sonestedt, Emily

AU - Idahl, Annika

AU - Lundin, Eva

AU - Wareham, Nicholas J

AU - Khaw, Kay-Tee

AU - Travis, Ruth C

AU - Ferrari, Pietro

AU - Riboli, Elio

AU - Gunter, Marc J

PY - 2016/1

Y1 - 2016/1

N2 - BACKGROUND: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.DESIGN: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).CONCLUSION: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.

AB - BACKGROUND: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.DESIGN: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).CONCLUSION: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.

KW - Adult

KW - Aged

KW - Carcinoma, Ovarian Epithelial

KW - Cohort Studies

KW - Diet/adverse effects

KW - Dietary Fats/adverse effects

KW - Fatty Acids/adverse effects

KW - Feeding Behavior

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasms, Glandular and Epithelial/etiology

KW - Netherlands

KW - Ovarian Neoplasms/etiology

KW - Risk Factors

U2 - 10.3945/ajcn.115.118588

DO - 10.3945/ajcn.115.118588

M3 - Article

C2 - 26607939

SN - 0002-9165

VL - 103

SP - 161

EP - 167

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 1

ER -

Merritt MA, Tzoulaki I, van den Brandt PA, Schouten LJ, Tsilidis KK, Weiderpass E et al. Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. American Journal of Clinical Nutrition. 2016 jan.;103(1):161-7. doi: 10.3945/ajcn.115.118588

Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

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