Sammanfattning
Background
Evidence suggests that diet could be a modifiable factor in the prevention of Alzheimeŕs disease (AD). High quality dietary patterns, such as the Mediterranean diet, has been suggested as protective, and lower quality dietary patterns, such as the western diet, has been suggested as a risk factor. Studies on the associations between dietary patterns and biomarker pathways for AD, are still limited. The aim of this study is to investigate the relation between dietary patterns and CSF biomarkers of relevance for AD in a sample of 70-year-olds from the general population.
Methods
Data was derived from the population based Gothenburg H70 Birth Cohort Studies in Gothenburg, Sweden (n=1203). There were 273 non-demented participants with dietary- and CSF data (49% women). CSF levels of β-amyloid (Aβ)42, total tau, and phosphorylated tau were measured with ELISA. Dietary intake was determined by the diet history method. Dietary intake was divided into food groups, and energy and nutrient intake were calculated. Statistical analyses were performed using general linear models, adjusted for energy intake, APOE4, BMI, education, and physical activity level.
Results
Lower levels of β-amyloid in CSF were associated with a higher intake of fast food (p=0.041), fiber (p=0.039), fiber-rich bread (p=0.004) and cereals (p=0.021) among men. Among women, lower levels of β-amyloid were associated with a higher intake of sweets (e.g. candy, sweet bakery) (p=0.022), before adjusting for covariates, but not after. Higher levels of total tau and phosphorylated tau were associated with a higher margarine intake (primarily butter-based) among men (p=0.033 and p=0.048). Among women, higher tau-levels were associated with a higher intake of soda (e.g. soft drink, lemonade) (p=0.003).
Conclusions
Preliminary results indicate that the intake of lower quality foods, such as fast food, butter-based margarines and soda, was related to more pathological levels of the CSF biomarkers. In men, we also found a relation between fibre, fibre-rich bread and cereals and more pathological levels. Fibre are considered healthy, but the dietary quality of fibre-rich bread and cereals can vary. Further analyses will be conducted using a Mediterranean dietary index and principal component analyses.
Evidence suggests that diet could be a modifiable factor in the prevention of Alzheimeŕs disease (AD). High quality dietary patterns, such as the Mediterranean diet, has been suggested as protective, and lower quality dietary patterns, such as the western diet, has been suggested as a risk factor. Studies on the associations between dietary patterns and biomarker pathways for AD, are still limited. The aim of this study is to investigate the relation between dietary patterns and CSF biomarkers of relevance for AD in a sample of 70-year-olds from the general population.
Methods
Data was derived from the population based Gothenburg H70 Birth Cohort Studies in Gothenburg, Sweden (n=1203). There were 273 non-demented participants with dietary- and CSF data (49% women). CSF levels of β-amyloid (Aβ)42, total tau, and phosphorylated tau were measured with ELISA. Dietary intake was determined by the diet history method. Dietary intake was divided into food groups, and energy and nutrient intake were calculated. Statistical analyses were performed using general linear models, adjusted for energy intake, APOE4, BMI, education, and physical activity level.
Results
Lower levels of β-amyloid in CSF were associated with a higher intake of fast food (p=0.041), fiber (p=0.039), fiber-rich bread (p=0.004) and cereals (p=0.021) among men. Among women, lower levels of β-amyloid were associated with a higher intake of sweets (e.g. candy, sweet bakery) (p=0.022), before adjusting for covariates, but not after. Higher levels of total tau and phosphorylated tau were associated with a higher margarine intake (primarily butter-based) among men (p=0.033 and p=0.048). Among women, higher tau-levels were associated with a higher intake of soda (e.g. soft drink, lemonade) (p=0.003).
Conclusions
Preliminary results indicate that the intake of lower quality foods, such as fast food, butter-based margarines and soda, was related to more pathological levels of the CSF biomarkers. In men, we also found a relation between fibre, fibre-rich bread and cereals and more pathological levels. Fibre are considered healthy, but the dietary quality of fibre-rich bread and cereals can vary. Further analyses will be conducted using a Mediterranean dietary index and principal component analyses.
| Originalspråk | Engelska |
|---|---|
| Sidor | P1210-P1210 |
| DOI | |
| Status | Publicerad - 2019-juni-01 |
| Evenemang | Alzheimer's Association International Conference - Los Angeles, USA Varaktighet: 2019-juli-14 → 2019-juli-18 |
Konferens
| Konferens | Alzheimer's Association International Conference |
|---|---|
| Land/Territorium | USA |
| Ort | Los Angeles |
| Period | 19-07-14 → 19-07-18 |
Nationell ämneskategori
- Näringslära och dietkunskap (30304)
Nyckelord
- Nutrition
- Dementia
- Older adults