TY - JOUR
T1 - Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
AU - Chajès, Véronique
AU - Jenab, Mazda
AU - Romieu, Isabelle
AU - Ferrari, Pietro
AU - Dahm, Christina C
AU - Overvad, Kim
AU - Egeberg, Rikke
AU - Tjønneland, Anne
AU - Clavel-Chapelon, Françoise
AU - Boutron-Ruault, Marie-Christine
AU - Engel, Pierre
AU - Teucher, Birgit
AU - Kaaks, Rudolf
AU - Floegel, Anna
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Dilis, Vardis
AU - Karapetyan, Tina
AU - Mattiello, Amalia
AU - Tumino, Rosario
AU - Grioni, Sara
AU - Palli, Domenico
AU - Vineis, Paolo
AU - Bueno-de-Mesquita, H Bas
AU - Numans, Mattijs E
AU - Peeters, Petra H M
AU - Lund, Eiliv
AU - Navarro, Carmen
AU - Quirós, Jose Ramón
AU - Sánchez-Cantalejo, Emilio
AU - Gurrea, Aurelio Barricarte
AU - Dorronsoro, Miren
AU - Regnér, Sara
AU - Sonestedt, Emily
AU - Wirfält, Elisabet
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Allen, Naomi E
AU - Crowe, Francesca L
AU - Rinaldi, Sabina
AU - Slimani, Nadia
AU - Carneiro, Fatima
AU - Riboli, Elio
AU - González, Carlos A
PY - 2011/11
Y1 - 2011/11
N2 - BACKGROUND: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored.OBJECTIVE: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST).DESIGN: Fatty acids were measured by gas chromatography in prediagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks.RESULTS: Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-γ-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), α-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to α-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66).CONCLUSION: These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, α-linolenic acid, and di-homo-γ-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk.
AB - BACKGROUND: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored.OBJECTIVE: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST).DESIGN: Fatty acids were measured by gas chromatography in prediagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks.RESULTS: Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-γ-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), α-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to α-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66).CONCLUSION: These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, α-linolenic acid, and di-homo-γ-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk.
KW - Adenocarcinoma/blood
KW - Adult
KW - Aged
KW - Case-Control Studies
KW - Cohort Studies
KW - Europe/epidemiology
KW - Fatty Acids/blood
KW - Female
KW - Humans
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Phospholipids/blood
KW - Risk Factors
KW - Stomach Neoplasms/blood
KW - Surveys and Questionnaires
U2 - 10.3945/ajcn.110.005892
DO - 10.3945/ajcn.110.005892
M3 - Article
C2 - 21993438
SN - 0002-9165
VL - 94
SP - 1304
EP - 1313
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 5
ER -
